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Mar Drugs ; 22(4)2024 Apr 19.
Article En | MEDLINE | ID: mdl-38667800

Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated by NMR and MS data. Compounds 2-4 exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC50 values of 41.6, 45.0, and 37.3 µM, respectively. Furthermore, compounds 3 and 4 significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds 3 and 4 may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.


Antineoplastic Agents , Colorectal Neoplasms , Epithelial-Mesenchymal Transition , Porifera , Terpenes , Humans , Animals , Antineoplastic Agents/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/isolation & purification , Porifera/chemistry , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/pathology , Terpenes/pharmacology , Terpenes/isolation & purification , Terpenes/chemistry , Epithelial-Mesenchymal Transition/drug effects , HCT116 Cells , Vascular Endothelial Growth Factor Receptor-1/metabolism , Vimentin/metabolism , Cell Line, Tumor , China
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